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Prof. Dr. Karina Reiß
Aktuelle Publikationen


2017

Keine Einträge

2016

Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K.
Phosphatidylserine exposure is required for ADAM17 sheddase function.
Nat Commun. 2016;7:11523
Sommer A, Bhakdi S, Reiss K.
How membrane asymmetry regulates ADAM17 sheddase function.
Cell Cycle 2016;27:1-2
Mohanty T, Alberius P, Schmidtchen A, Reiss K, Schröder JM, Sørensen OE.
Saliva induces expression of antimicrobial peptides and promotes intracellular killing of bacteria in keratinocytes by EGFR-transactivation.
Br J Dermatol. 2016;[Epub ahead of print]

2015

Speck N, Brandsch C, Schmidt N, Yazdekhasti N, Hirche F, Lucius R, Rimbach G, Stangl GI, Reiss K
The antiatherogenic effect of fish oil in male mice is associated with a diminished release of endothelial adam17 and adam10 substrates.
The Journal of nutrition 2015;145:1218-1226
Maretzky T, Evers A, Le Gall S, Alabi RO, Speck N, Reiss K, Blobel CP
The cytoplasmic domain of a disintegrin and metalloproteinase 10 (adam10) regulates its constitutive activity but is dispensable for stimulated adam10-dependent shedding.
The Journal of biological chemistry 2015;290:7416-7425
Dusterhoft S, Michalek M, Kordowski F, Oldefest M, Sommer A, Roseler J, Reiss K, Grotzinger J, Lorenzen I
Extracellular juxtamembrane segment of adam17 interacts with membranes and is essential for its shedding activity.
Biochemistry (Mosc) 2015;54:5791-5801
Maretzky T, Evers A, Le Gall S, Alabi RO, Speck N, Reiss K, Blobel CP
The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding.
J Biol. Chem. 2015;290(12):7416-25

2014

Fischer J, Wu Z, Kantyka T, Sperrhacke M, Dimitrieva O, Koblyakova Y, Ahrens K, Graumann N, Baurecht H, Reiss K, Schröder JM, Proksch E, Meyer-Hoffert U
Characterization of Spink6 in Mouse Skin: The Conserved Inhibitor of Kallikrein-Related Peptidases Is Reduced by Barrier Injury.
J Invest Dermatol. 2014;134(5):1305-12
Dasari P, Fries A, Heber SD, Salama A, Blau IW, Lingelbach K, Bhakdi SC, Udomsangpetch R, Torzewski M, Reiss K, Bhakdi S.
Malarial anemia: digestive vacuole of Plasmodium falciparum mediates complement deposition on bystander cells to provoke hemophagocytosis.
Med Microbiol Immunol. 2014;203(6):383-93
Groot AJ, Habets R, Yahyanejad S, Hodin CM, Reiss K, Saftig P, Theys J, Vooijs M.
Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins.
Mol Cell Biol. 2014;34(15):2822-32.
Piegholdt S, Pallauf K, Esatbeyoglu T, Speck N, Reiss K, Ruddigkeit L, Stocker A, Huebbe P, Rimbach G.
Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-?B, and tyrosine phosphorylation.
Free Radic Biol Med.  2014;70:255-64.

2013

Keine Einträge

2012

Sommer A, Fries A, Cornelsen I, Speck N, Koch-Nolte F, Gimpl G, Andrae J, Bhakdi S, Reiss K.
Melittin modulates keratinocyte function through P2-receptor-dependent ADAM activation.
J Biol Chem. 2012;Epub ahead of print
Dasari P, Heber SD, Beisele M, Torzewski M, Reifenberg K, Orning C, Fries A, Zapf AL, Baumeister S, Lingelbach K, Udomsangpetch R, Bhakdi SC, Reiss K, Bhakdi S.
Digestive vacuole of Plasmodium falciparum released during erythrocyte rupture dually activates complement and coagulation.
Blood 2012;119(8):4301-10
Tharmarajah G, Faas L, Reiss K, Saftig P, Young A, Van Raamsdonk CD
Adam10 haploinsufficiency causes freckle-like macules in Hairless mice.
Pigment Cell Melanoma Res 2012;25(5):555-565

2011

Saftig P, Reiss K.
The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: Novel drug targets with therapeutic potential?
Eur J Cell Biol. 2011;90, 527-535
Dasari P, Reiss K, Lingelbach K, Baumeister S, Lucius R, Udomsangpetch R, Bhakdi SC, Bhakdi S
Digestive vacuoles of Plasmodium falciparum are selectively phagocytosed by and impair killing function of polymorphonuclear leukocytes.
Blood.  2011;Nov 3;118(18):4946-56
Reiss K, Meyer-Hoffert U, Fischer J, Sperrhacke M, Wu Z, Dimitrieva O, Krenek P, Suchanova S, Buryova H, Brauer R, Sedlacek R
Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2.
Exp Dermatol.  2011;Nov;20(11):905-10
Reiss K, Cornelsen I, Husmann M, Gimpl G, Bhakdi S
Unsaturated fatty acids drive disintegrin and metalloproteinase (ADAM)-dependent cell adhesion, proliferation, and migration by modulating membrane fluidity.
J Biol Chem.  2011;Jul 29;286(30):26931-42
Kantyka T, Fischer J, Wu Z, Declercq W, Reiss K, Schröder JM, Meyer-Hoffert U
Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6.
Peptides 2011;Jun;32(6):1187-92
Maretzky T, Evers A, Zhou W, Swendeman SL, Wong PM, Rafii S, Reiss K, Blobel CP
Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17.
Nat Commun 2011;2:229
Pahl R, Brunke G, Steubesand N, Schubert S, Böttner M, Wedel T, Jürgensen C, Hampe J, Schäfer H, Zeissig S, Schreiber S, Rosenstiel P, Reiss K, Arlt A
IL-1β and ADAM17 are central regulators of β-defensin expression in Candida esophagitis.
Am J Physiol Gastrointest Liver Physiol 2011;300(4):G547-53
Kantyka T, Fischer J, Wu Z, Declercq W, Reiss K, Schröder JM, Meyer-Hoffert U
Inhibition of Kallikrein-related Peptidases by the Serine Protease Inhibitor of Kazal-type 6
Peptides 2011;32:1187-92
Reiss K, Meyer-Hoffert U; Fischer J; Sperrhacke M; Wu Z; Dimitrieva O; Krenek P; Buryova H; Suchanova S; Brauer R; Sedlacek, R
Expression and regulation of murine LEKTI2
Exp Dermatol 2011;20:905-10

2010

Müller M, Beck IM, Gadesmann J, Karschuk N, Paschen A, Proksch E, Djonov V, Reiss K, Sedlacek R.
MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells.
Mod. Pathol. 2010;23(4):511-521
Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S.
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
J Exp Med. 2010;207(8):1617-1624
Le Gall SM, Maretzky T, Issuree PD, Niu XD, Reiss K, Saftig P, Khokha R, Lundell D, Blobel CP.
ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site.
J Cell Sci. 2010;123(Pt 22):3913-22
Jung S, Mysliwy J, Spudy B, Lorenzen I, Reiss K, Gelhaus C, Podschun R, Leippe M, Grötzinger J.
Human {beta}-defensin2 and {beta}-defensin3 chimeric peptides reveal the structural basis of the pathogen specificity of their parent molecules.
Antimicrob Agents Chemother 2010;Epub:ahead of print

2009

Huth T, Schmidt-Neuenfeldt K, Rittger A, Saftig P, Reiss K*, Alzheimer C
Non-proteolytic effect of beta-site APP-cleaving enzyme 1 (BACE1) on sodium channel function.
Neurobiol Dis.  2009;33:282-9
Le Gall S, Bobé P, Reiss K, Horiuchi K, Niu XD, Lundell D, Gibb DR, Conrad D, Saftig P, Blobel CP
ADAMs 10 and 17 are differentially regulated components of the sheddingmachinery for TGF?, TNF? and other membrane proteins.
Mol Biol Cell. 2009;20:1785-1794
Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss K, Maes E, Snellinx A, Serneels L, Nyabi O, Annaert W, Saftig P, Hartmann D, De Strooper B
ADAM10, The rate-limiting protease of regulated intramembrane proteolysis of Noch and other proteins, is processed by ADAMs9,-15, and the Gamma Secreates.
J Biol Chem.  2009;284:11738-11747
Foveau B, Ancot F, Leroy C, Petrelli A, Reiss K, Vingtdeux V, Giordano S, Fafeur V, Tulasne D
Downregulation of the Met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis.
Mol Biol Cell. 2009;
Koenen RR, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, Reiss K, Sarabi A, Lindbom L, Hackeng TM, Weber C, Ludwig A
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinase.
Blood 2009;
Reiss K, Saftig P
The "A Disintegrin And Metalloprotease" (ADAM) family of sheddases: Physiological and cellular functions.
Semin Cell Dev Biol. 2009;20:126-37
Liu Q, Zhang J, Tran H, Verbeek MM, Reiss K, Estus S, Bu G
LRP1 shedding in human brain: roles of ADAM10 and ADAM17
Mol Neurodegener 2009;4:17

2008

Martin L, Fluhrer R, Reiss K, Saftig P, Haass C
Regulated Intramembrane Proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/b.
J Biol Chem. 2008;283:1644-1652
Maretzky T, Scholz F, Köten B, Proksch E, Saftig P, Reiss K
ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis.
J Invest Dermatol 2008;128(7):1737-46
Schulz B, Pruessmeyer J, Maretzky T, Ludwig A, Blobel C, Saftig P, Reiss K
Disintegrin Metalloprotease (ADAM) 10 Regulates Endothelial Permeability and T Cell Transmigration by Proteolysis of Vascular Endothelial Cadherin
Circ Res.  2008;102:1192-1201
Raucci A, Cugusi S, Antonelli A, Barabino SM, Monti L, Bierhaus A, Reiss K, Saftig P, Bianchi ME
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10).
FASEB J.  2008;22:3716-3727
Deuss M, Reiss K, Hartmann D
Part time alpha-secretases: the functional biology of ADAM9, 10 and 17.
Curr. Alz. Res. 2008;5:187-201
Fiorilli P, Partridge D, Staniszewska I, Wang JY, Grabacka M, So K, Marcinkiewicz C, Reiss K, Khalili K, Croul SE.
Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferation.
Lab Invest 2008;88(11):1143-56
Schulz B, Pruessmeyer J, Maretzky T, Ludwig A, Blobel CP, Saftig P, Reiss K.
ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.
Circ Res. 2008;102(10):1192-201

2007

Horiuchi K, Le Gall S, Schulte M, Yamaguchi T, Reiss K, Murphy G, Toyama Y, Hartmann D, Saftig P, Blobel CP
Substrate Selectivity and Regulation of EGF-Receptor Ligand Sheddases by Phorbol Esters and Calcium Influx.
Mol Biol Cell. 2007;18:176-188
Schulte M, Reiss K*, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P
ADAM10 modulates FasL-induced cytotoxicity and activation-induced cell death of T lymphocytes.
Cell Death Differ. 2007;14:1040-1049
Schulte A, Schulz B, Andrzejewski M G, Hundhausen C, Mletzko S, Achilles J, Reiss K, Paliga K, Weber C, Rose J S, Ludwig A
Sequential processing of the transmembrane chemokines CX3CL1 and CXCL16 by alpha- and gamma-secretases.
Biochem Bioph Res Co. 2007;358:233-240
Hundhausen C, Schulte A, Schulz B, von Hundelshausen P, Achilles J, Winter U, Paliga K, Reiss K, Saftig P, Weber C, Ludwig A
Regulated shedding of transmembrane chemokines by the metalloproteinase ADAM10 facilitates detachment of adherent leukocytes.
J Immunology 2007;178:8064-8072

2006

Reiss K, Maretzky T*, Haas IG, Schulte M, Ludwig A, Frank M, Saftig P
Regulated ADAM10-dependent Ectodomain Shedding of {gamma}-Protocadherin C3 Modulates Cell-Cell Adhesion.
J Biol Chem 2006;281:21735-21744
Reiss K, Ludwig A, Saftig P
Breaking up the tie: Disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion.
Pharmacol Therapeut 2006;111:985-1006
Tousseyn T, Jorissen E, Reiss K, Hartmann D
(Make) stick and cut loose--disintegrin metalloproteases in development and disease.
Birth Defects Res C Embryo Today 2006;78:24-46

2005

Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P.
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME 2005;102:9182-9187
Reiss K, Maretzky T*, Ludwig A, Tousseyn T, De Strooper B, Hartmann D, Saftig P
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling.
EMBO J 2005;24:742-752
Maretzky T, Schulte M, Ludwig A, Rose-John S, Blobel C, Hartmann D, Altevogt P, Saftig P, Reiss K
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth.
Mol Cell Biol 2005;25:9040-9053
Ludwig A, Schulte A, Schnack C, Hundhausen C, Reiss K, Brodway N, Held-Feindt J, Mentlein R
Enhanced expression and shedding of the transmembrane chemokine CXCL16 by reactive astrocytes and glioma cells.
J Neurochem 2005;93:1293-1303
Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, Moechars D, Alzheimer C, Reiss K, Saftig P, De Strooper B
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.
J Biol Chem 2005;280:30797-30806
D'Hooge R, Lullmann-Rauch R, Beckers T, Balschun D, Schwake M, Reiss K, von Figura K, Saftig P
Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis.
J Neurosci 2005;25:6539-6549

2004

Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.
J Biol Chem 2004;279:53205-53212
Suttmann H, Jacobsen M, Reiss K, Jocham D, Bohle A, Brandau S
Mechanisms of bacillus Calmette-Guerin mediated natural killer cell activation.
J Urology 2004;172:1490-1495

2003

Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
J Biol Chem 2003;278:48713-48719
Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Blood 2003;102:1186-1195
Gamp AC, Tanaka Y, Lullmann-Rauch R, Wittke D, D'Hooge R, De Deyn PP, Moser T, Maier H, Hartmann D, Reiss K, Illert AL, von Figura K, Saftig P
LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice.
Hum Mol Genet 2003;12:631-646

2002

Reiss K, Mentlein R, Sievers J, Hartmann D
Stromal cell-derived factor 1 is secreted by meningeal cells and acts as chemotactic factor on neuronal stem cells of the cerebellar external granular layer.
Neuroscience 2002;115:295-305

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