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PD Dr. Dr. med. Ulf Meyer-Hoffert
Aktuelle Publikationen


2017

Keine Einträge

2016

Jung S, Fischer J, Spudy B, Kerkow T, Sönnichsen FD, Xue L, Bonvin AM, Goettig P, Magdolen V, Meyer-Hoffert U, Grötzinger J.
The solution structure of the kallikrein-related peptidases inhibitor SPINK6.
Biochem Biophys Res Commun. 2016;471(1):103-8
Redelfs L, Fischer J, Weber C, Wu Z, Meyer-Hoffert U
The serine protease inhibitor of Kazal-type 9 (SPINK9) is expressed in lichen simplex chronicus, actinic keratosis and squamous cell carcinoma.
Arch Dermatol Res. 2016;308(2):133-7

2015

Schaarschmidt H, Ellinghaus D, Rodríguez E, Kretschmer A, Baurecht H, Lipinski S, Meyer-Hoffert U, Harder J, Lieb W, Novak N, Fölster-Holst R, Esparza-Gordillo J, Marenholz I, Ruschendorf F, Hubner N, Reischl E, Waldenberger M, Gieger C, Illig T, Kabesch M, Zhang XJ, Xiao FL, Lee YA, Franke A, Weidinger S
A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis
J Allergy Clin Immunol. 2015;136(3):802-6

2014

Fischer J, Wu Z, Kantyka T, Sperrhacke M, Dimitrieva O, Koblyakova Y, Ahrens K, Graumann N, Baurecht H, Reiss K, Schröder JM, Proksch E, Meyer-Hoffert U
Characterization of Spink6 in Mouse Skin: The Conserved Inhibitor of Kallikrein-Related Peptidases Is Reduced by Barrier Injury.
J Invest Dermatol. 2014;134(5):1305-12
Gläser R, Becker K, von Eiff C, Meyer-Hoffert U, Harder J
Decreased susceptibility of Staphylococcus aureus small colony variants (SCVs) towards human antimicrobial peptides
Journal of Investigative Dermatology 2014;134(9):2347-50

2013

Fischer J, Koblyakova Y, Latendorf T, Wu Z, Meyer-Hoffert U
Cross-linking of SPINK6 by Transglutamination Protects from Epidermal Proteases
J Invest Dermatol 2013;in press
Simanski M, Gläser R, Köten B, Meyer-Hoffert U, Wanner S, Weidenmaier C, Peschel A, Harder J
Staphylococcus aureus subverts cutaneous defense by D-alanylation of teichoic acids.
Exp Derm 2013;22(4):294-296
Wittersheim M, Cordes J, Meyer-Hoffert U, Harder J, Hedderich J, Gläser R
Differential Expression and in vivo Secretion of the Antimicrobial Peptides Psoriasin (S100A7), RNase 7, human beta-Defensin-2 and -3 in Healthy Human Skin.
Exp Derm 2013;22(5):264-366
Olliver M, Spelmink L, Hiew J, Meyer-Hoffert U, Henriques-Normark B, Bergman P
Immunomodulatory Effects of Vitamin D on Innate and Adaptive Immune Responses to Streptococcus pneumoniae
J Infect Dis 2013;208(9):1474-1481
Ellinghaus D, Baurecht H, Esparza-Gordillo J, Rodriguez E, Matanovic A, Marenholz I, Hubner N, Schaarschmidt H, Novak N, Michel S, Maintz L, Werfel T, Meyer-Hoffert U, Hotze M, Prokisch H, Heim K, Herder C, Hirota T, Tamari M, Kubo M, Takahashi A, Nakamura Y, Tsoi LC, Stuart P, Elder JT, Sun L, Zuo X, Yang S, Zhang X, Hoffmann P, Nothen MM, Folster-Holst R, Winkelmann J, Illig T, Boehm BO, Duerr RH, Buning C, Brand S, Glas J, McAleer MA, Fahy CM, Kabesch M, Brown S, McLean WH, Irvine AD, Schreiber S, Lee YA, Franke A, Weidinger S
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis
Nat Genet 2013;45: 808-812
Meyer-Hoffert U, Brasch J
Allergic contact dermatitis caused by betulin-containing triterpene extract from the outer bark of birch (Betula alba)
Contact Dermatitis 2013;68: 382-383
Meyer-Hoffert U, Jensen JM, Brasch J
Exanthema caused by ingestion of potassium p-aminobenzoate (POTABA-Glenwood((R))
Contact Dermatitis 2013;68: 381-382
Jaeger SU, Schroeder BO, Meyer-Hoffert U, Courth L, Fehr SN, Gersemann M, Stange EF, Wehkamp J
Cell-mediated reduction of human beta-defensin 1: a major role for mucosal thioredoxin
Mucosal Immunol 2013;6(6):1179-90
Fischer J, Meyer-Hoffert U
Regulation of kallikrein-related peptidases in the skin - from physiology to diseases to therapeutic options
Thromb Haemost 2013;110: 442-449
Fischer J, Koblyakova Y, Latendorf T, Wu Z, Meyer-Hoffert U
Cross-linking of SPINK6 by transglutaminases protects from epidermal proteases
J Invest Dermatol 2013;133: 1170-1177
Sina C, Lipinski S, Gavrilova O, Aden K, Rehman A, Till A, Rittger A, Podschun R, Meyer-Hoffert U, Haesler R, Midtling E, Putsep K, McGuckin MA, Schreiber S, Saftig P, Rosenstiel P
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice
Gut 2013;62: 520-530
Meyer-Hoffert U, Jensen JM, Brasch J
Exanthema caused by ingestion of potassium p-aminobenzoate (POTABA-Glenwood(®) )
Contact Dermatitis 2013;68(6):381-2

2012

Hansmann B, Ahrens K, Wu Z, Proksch E, Meyer-Hoffert U, Schröder JM
Murine filaggrin-2 is involved in epithelial barrier function and down-regulated in metabolically induced skin barrier dysfunction.
Exp Dermal 2012;21(4):271-6
Sina C, Lipinski S, Gavrilova O, Aden K, Rehman A, Till A, Rittger A, Podschun R, Meyer-Hoffert U, Haesler R, Midtling E, Pütsep K, McGuckin MA, Schreiber S, Saftig P, Rosenstiel P
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice.
Gut 2012;in Press
Dössel J, Meyer-Hoffert U, Schröder JM, Gerstel U
Pseudomonas aeruginosa-derived rhamnolipids subvert the host innate immune response through manipulation of the human beta-defensin-2 expression
Cell Microbiol. 2012;14(9):1364-75
Köten B, Becker K, Podschun R, von Eiff C, Meyer-Hoffert U, Harder J, Gläser R
Susceptibility of Staphylococcus aureus bacteremia strains to different skin-derived antimicrobial proteins.
Arch Dermatol Res 2012;304(8):633-7
Meyer-Hoffert U
Innate Immunity in the Skin.
J Innate Immun 6 2012;4(3):223-224

2011

Meyer- Hoffert U, Zimmermann A, Czapp M, Bartels J, Koblyakova Y, Gläser R, Schröder JM, Gerstel U
Flagellin Delivery by Pseudomonas aeruginosa Rhamnolipids Induces the Antimicrobial Protein Psoriasin in Human Skin.
PLoS One 2011;25;6(1): e16433
Gläser R, Meyer-Hoffert U, Harder J
Staphylokokken
Fortschritte der praktischen Dermatologie und Venerologie 2010 (Hrsg.Ruzicka, Th.; Wolff, H.; Thomas, P.; Prinz) 2011;S 242-246
Kantyka T, Fischer J, Wu Z, Declercq W, Reiss K, Schröder JM, Meyer-Hoffert U
Inhibition of Kallikrein-related Peptidases by the Serine Protease Inhibitor of Kazal-type 6
Peptides 2011;32:1187-92
Wu Z, Latendorf T, Meyer-Hoffert U, Schröder JM
Identification of Trychohyalin2, a new member of the filaggrin family
J Invest Dermatol 2011;131:1761-3
Meyer-Hoffert U, Zimmermann A, Czapp M, Gläser R, Kobliakova J, Schröder JM, Gerstel U
Rhamnolipids from Pseudomonas aeruginosa enable flagellin induction of antimicrobial psoriasin expression in human skin
PLoS ONE 2011;6:e16433
Reiss K, Meyer-Hoffert U; Fischer J; Sperrhacke M; Wu Z; Dimitrieva O; Krenek P; Buryova H; Suchanova S; Brauer R; Sedlacek, R
Expression and regulation of murine LEKTI2
Exp Dermatol 2011;20:905-10
Meyer-Hoffert U, Wiedow O
Neutrophil Serine Proteases – Mediators of Innate Immune Responses
Curr Opin Hematol 2011;18:19-24
Meyer-Hoffert U, Schröder JM
Epidermal Proteases in the Pathogenesis of Rosacea
J Investig Dermatol Symp Proc 2011;15(1):16-23

2010

Harder J, Dressel S, Wittersheim M, Cordes J, Meyer-Hoffert U, Mrowietz U, Fölster-Holst R, Proksch E, Schröder JM, Schwarz T, Gläser R
Enhanced expression an secretion of antimicrobial peptides in atopic dermatitis an after superficial skin injury
J Invest Dermatol 2010;130(5):1355-64
Meyer-Hoffert U, Schröder JM, Schwarz T, Gläser R
Increased Expression of human beta-Defensin 3 in Mollusca contagiosa
Clin Exp Dermatol 2010;35:190-192
Dressel s, Harder J, Cordes J, Wittersheim M, Meyer-Hoffert U, Sunderkötter C, Gläser R
Differential expression of antimicrobial peptides in margins of chronic wounds
Exp Dermatol 2010;Exp Dermatol 19(7):628-32
Meyer-Hoffert U, Wu Z, Kantyka T, Fischer J, Latendorf T, Hansmann B, Bartels J, He Y, Gläser R, Schröder JM.
Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases.
J Biol Chem 2010;285(42):32174-81

2009

Gläser R, Meyer-Hoffert U, Harder J, Cordes J, Wittersheim M, Kobliakova J, Fölster-Holst R, Proksch E, Schröder JM, Schwarz T
The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption.
J Invest Dermatol. 2009;129(3):641-9
Wu Z, Meyer-Hoffert U, Reithmayer K, Paus R, Hansmann B, He Y, Bartels J, Gläser R, Harder J, Schröder JM.
Highly Complex Peptide Aggregates of the S100 Fused-Type Protein Hornerin Are Present in Human Skin.
J Invest Dermatol 2009;129(6):1446-58
Kantyka T, Latendorf T, Wiedow O, Bartels J, Gläser R, Dubin G, Schröder JM, Potempa J, Meyer-Hoffert U.
Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage.
BIOL CHEM 2009;390(12): 1313-1320
Meyer-Hoffert U.
Reddish, scaly, and itchy: how proteases and their inhibitors contribute to inflammatory skin diseases.
Arch Immunol Ther Exp (Warsz) 2009;57(5):345-54
Gläser R, Meyer-Hoffert U, Harder J.
Antimicrobial peptides in atopic dermatitis. A paradigm shift?
Hautarzt 2009;60(9):761-2
Meyer-Hoffert U, Wu Z, Schröder JM.
Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor.
PLoS One 2009;4(2):e4372
Wu Z, Hansmann B, Meyer-Hoffert U, Gläser R, Schröder JM.
Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family.
PLoS One 2009;4(4):e5227

2008

Meyer-Hoffert U, Schwarz T, Schröder JM, Gläser R
Expression of human beta-defensin-2 and -3 in verrucae vulgares and condylomata acuminata.
J Eur Acad Dermatol Venereol. 2008;22(9):1050-4
Meyer-Hoffert U, Hornef MW, Henriques-Normark B, Axelsson LG, Midtvedt T, Pütsep K, Andersson M.
Secreted enteric antimicrobial activity localises to the mucus surface layer.
GUT 2008;57(6):764-71
Meyer-Hoffert U, Hornef M, Henriques-Normark B, Normark S, Andersson M, Pütsep K.
Identification of heparin/heparan sulfate interacting protein as a major broad-spectrum antimicrobial protein in lung and small intestine.
FASEB J 2008;22(7):2427-34

2007

Keine Einträge

2006

Keine Einträge

2005

Wiedow O, Meyer-Hoffert U
Neutrophil Serine Proteases: Potential Key Regulators of Cell Signaling during Inflammation
JOURNAL OF INTERNAL MEDICINE 2005;257:319-328
Varoga D, Pufe T, Harder J, Schröder JM, Mentlein R, Meyer-Hoffert U, Goldring MB, Tillmann B, Hassenpflug J, Paulsen F.
Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitors.
Arthritis Rheum 2005;52(6):1736-45
Albiger B, Sandgren A, Katsuragi H, Meyer-Hoffert U, Beiter K, Wartha F, Hornef M, Normark S, Normark BH.
Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice.
Cell Microbiol 2005;7(11):1603-15

2004

Meyer-Hoffert U, Rogalski C, Seifert S, Schmeling G, Wingertszahn J, Proksch E, Wiedow O.
Trypsin induces epidermal proliferation and inflammation in murine skin
EXPERIMENTAL DERMATOLOGY 2004;13:234-241
Meyer-Hoffert U, Wingertszahn J, Wiedow O
Human leukocyte elastase induces keratinocytes proliferation by epidermal growth factor receptor activation
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2004;123:338-345
Varoga D, Pufe T, Harder J, Meyer-Hoffert U, Mentlein R, Schroder JM, Petersen WJ, Tillmann BN, Proksch E, Goldring MB, Paulsen FP
Production of endogenous antibiotics in articular cartilage
ARTHRITIS AND RHEUMATISM 2004;50:3526-3534
Harder J, Meyer-Hoffert U, Wehkamp K, Schwichtenberg L, Schroder JM
Differential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2004;123:522-529
Tralau T, Meyer-Hoffert U, Schröder JM, Wiedow O.
Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis.
Exp Dermatol 2004;13(5):316-25

2003

Meyer-Hoffert U, Wichmann N, Schwichtenberg L, White PC, Wiedow O
Supernatants of Pseudomonas aeruginosa induce the Pseudomonas-specific antibiotic elafin in human keratinocytes.
EXPERIMENTAL DERMATOLOGY  2003;12:418-425
Meyer-Hoffert U, Lezcano-Meza D, Bartels J, Montes-Vizuet AR, Schröder JM and Teran LM
Th2- and to a lesser extent Th1-type cytokines upregulate the production of both CXC (IL-8 and gro-alpha) and CC (RANTES, eotaxin, eotaxin-2, MCP-3 and MCP-4) chemokines in human airway epithelial cells.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY  2003;264-271

2002

Rogalski, C., Meyer-Hoffert, U., Proksch, E., Wiedow, O.
Human leukocyte elastase induces keratinocyte proliferation in vitro and in vivo.
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2002;118:49-54

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