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Prof. Dr. med. Regine Gläser
Aktuelle Publikationen


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Bierkarre H, Harder J, Cuthbert R, Emery P, Leuschner I Mrowietz U, Hedderich J, McGonagle D, Gläser R
Differential expression of antimicrobial peptides in psoriasis and psoriatic arthritis as a novel contributory mechanism for skin and joint disease heterogeneity
Scand J Rheumatol 2016;45(3):188-96
Bayer A, Lammel J, Rademacher F, Groß J, Siggelkow M, Lippross S, Klüter T, Varoga D, Tohidnezhad M, Pufe T, Cremer J, Gläser R, Harder J.
Platelet-released growth factors induce the antimicrobial peptide human beta-defensin-2 in primary keratinocytes.
Exp Dermatol. 2016;Epub ahead of print
Simanski M, Rademacher F, Schröder L, Gläser R, Harder J.
The Inflammasome and the Epidermal Growth Factor Receptor (EGFR) Are Involved in the Staphylococcus aureus-Mediated Induction of IL-1alpha and IL-1beta in Human Keratinocytes.
PLoS One 2016;Jan 25;11(1):e0147118


Kunz M, König IR, Schillert A, Kruppa J, Ziegler A, Grallert H, Müller-Nurasyid M, Lieb W, Franke A, Ranki A, Panelius J, Koskenmies S, Hasan T, Kere J, Rönn AC, Simon JC, Schmidt E, Wenzel J, Tüting T, Landsberg J, Zeller T, Blankenberg S, Gläser R, Patsinakidis N, Kuhn A, Ibrahim SM
Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus
Exp. Dermatol. 2015;24:510-5
Chalmers JR, Wojnarowska F, Kirtschig G, Nunn AJ, Bratton DJ, Mason J, Foster KA, Whitham D, Williams HC; BLISTER study group
A randomized controlled trial to compare the safety and effectiveness of doxycycline (200 mg daily) with oral prednisolone (0·5 mg kg(-1) daily) for initial treatment of bullous pemphigoid: a protocol for the Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) Trial
Br J Dermatol 2015;173:227-34
Recke A, Vidarsson G, Ludwig RJ, Freitag M, Möller S, Vonthein R, Schellenberger J, Haase O, Görg S, Nebel A, Flachsbart F, Schreiber S, Lieb W, Gläser R, Benoit S, Sárdy M, Eming R, Hertl M, Zillikens D, König IR, Schmidt E, Ibrahim S; German AIBD Genetic Study Group
Allelic and copy-number variations of Fc?Rs affect granulocyte function and susceptibility for autoimmune blistering diseases.
J Autoimmunl 2015;61:36-44
Hirose M, Schilf P, Benoit S, Eming R, Gläser R, Homey B, Kunz M, Nebel A, Peitsch WK, Pföhler C, Sárdy M, Schreiber S, Zillikens D, Schmidt E, Ibrahim SM; German AIBD Genetic Study Group
Polymorphisms in the mitochondrially encoded ATP synthase 8 gene are associated with susceptibility to bullous pemphigoid in the German population
Exp Dermatol 2015;24:715-7
Gläser R, Weidinger A
New classification criteria for systemic sclerosis taking into account capillaroscopy
Hautarzt 2015;66:487-8


Cordes J, Wittersheim M, Harder J, Gläser R
The skin's own antibiotics : Important features of antimicrobial peptides for clinical practice.
Hautarzt 2014;65(1):50-55
Daeschlein G, Gläser R
[Infections in dermatology].
Hautarzt 2014;65(1):50-5
Steinz K, Schubert S, Harder J, Gerdes S, Mrowietz U, Gläser R.
Bacterial soft tissue infection in psoriasis despite induction of epidermal antimicrobial peptides.
Exp. Dermatol. 2014;23(11):862-4
Simanski M, Gläser R, Harder J
Human skin engages different epidermal layers to provide distinct innate defense mechanisms.
Exp Dermatol 2014;23(4):230-231
Gläser R, Becker K, von Eiff C, Meyer-Hoffert U, Harder J
Decreased susceptibility of Staphylococcus aureus small colony variants (SCVs) towards human antimicrobial peptides
Journal of Investigative Dermatology 2014;134(9):2347-50
Kuhn A, Sigges J, Biazar C, Ruland V, Patsinakidis N, Landmann A, Amler S, Bonsmann G; EUSCLE coauthors
Influence of smoking on disease severity and antimalarial therapy in cutaneous lupus erythematosus: analysis of 1002 patients from the EUSCLE database.
Br. J. Dermatol. 2014;171:571-9


Felton S, Navid F, Schwarz A, Schwarz T, Gläser R, Rhodes LE
Ultraviolet radiation-induced upregulation of antimicrobial proteins in health and disease.
Photochem Photobiol Sci. 2013;12(1):29-36
Harder J, Schröder JM, Gläser R
The skin surface as antimicrobial barrier: present concepts and future outlooks.
Exp. Dermatol. 2013;22:1-5
Gläser R, Gerdes S
Does the risk of cardiovascular complications decrease in psoriatic patients receiving systemic therapy?
Hautarzt 2013;64:63-64
Simanski M, Rademacher F, Schröder L, Gläser R, Harder J
IL-17A and IFN-gamma synergistically induce RNase 7 expression via STAT3 in primary keratinocytes.
PLOS ONE 2013;8(3):e59531
Simanski M, Gläser R, Köten B, Meyer-Hoffert U, Wanner S, Weidenmaier C, Peschel A, Harder J
Staphylococcus aureus subverts cutaneous defense by D-alanylation of teichoic acids.
Exp Derm 2013;22(4):294-296
Wittersheim M, Cordes J, Meyer-Hoffert U, Harder J, Hedderich J, Gläser R
Differential Expression and in vivo Secretion of the Antimicrobial Peptides Psoriasin (S100A7), RNase 7, human beta-Defensin-2 and -3 in Healthy Human Skin.
Exp Derm 2013;22(5):264-366
Kuhn A, Sigges J, Biazar C, Landmann A, Ruland V, Patsinakidis N, Amler S, Bonsmann G, the EUSCLE Co-Authors
Therapeutic strategies evaluated by the European society of cutaneous lupus erythematosus (EUSCLE) core set questionnaire in more than 1000 patients with cutaneous lupus erythematosus.
Autoimmun Rev. 2013;12(7):694-702
Biazar C, Sigges J, Patsinakidis N, Ruland V, Amler S, Bonsmann G, Kuhn A, EUSCLE co-authors.
Cutaneous lupus erythematosus: first multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE).
Autoimmun Rev. 2013;12:444-454
Schuster C, Gläser R, Fiala C, Eppel W, Harder J, Schröder JM, Elbe-Bürger A
Prenatal human skin expresses the antimicrobial peptide Rnase 7
Arch Derm Res 2013;305(6):545.549
Gläser R
New nomenclature for the vasculitides
Hautarzt 2013;64(11):868-869
Lüthje P, Brauner H, Ramos NL, Ovregaard A, Gläser R, Hirschberg AL, Aspenström P, Brauner A
Estrogen supports urothelial defense mechanisms
Sci Transl Med 2013;5(190):190ra80


Köten B, Becker K, Podschun R, von Eiff C, Meyer-Hoffert U, Harder J, Gläser R
Susceptibility of Staphylococcus aureus bacteremia strains to different skin-derived antimicrobial proteins.
Arch Dermatol Res 2012;304(8):633-7
Gläser R, Homey B
Infectious diseases of the skin
Hautarzt 2012;63(5):370
Gläser R
Belimumab. A new targeted therapeutic option for lupus erythematosus
Hautarzt 2012;63(3):253-4
Westermann L, Hügel R, Meier M, Weichenthal M, Zillikens D, Gläser R, Schmidt E
Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption
J Dermatol. 2012;39(2):168-71
Simanski M, Köten B, Schröder JM, Gläser R, Harder J
Antimicrobial Rnases in cutaneous defense.
J Innate Immun. 2012;4(3):241-7
van Beek N, Knuth-Rehr D, Altmeyer P, Assaf C, Babilas P, Bayerl C, Benoit S, Dippel E, Effendy I, Eming R, Fischer M, Glaenz T, Gläser R, Goebeler M, Gollnick H, Götze S, Gross G, Hadaschik E, Herbst R, Hermes B, Homey B, Hunzelmann N, Jünger M, Kapp A, Kern JS, Körber A, Luger T, Mechtel D, Megahed M, Moll I, Peters KP, Pfeiffer C, Ring J, Röcken M, Sárdy M, Seitz CS, Stadler R, Steinbrink K, Sticherling M, Szeimies RM, Tronnier M, Ulrich J, Vogt T, Wagner N, Welzel J, Wenzel J, Wozel G, Zouboulis CC, Zillikens D, Schmidt E
Diagnostics of autoimmune bullous diseases in German dermatology departments.
J Dtsch Dermatol Ges. 2012;10(7):492-9
Emelianov VU, Bechara FG, Gläser R, Langan EA, Taungjaruwinai WM, Schröder JM, Meyer KC, Paus R
Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa/acne inversa.
Br J Dermatol. 2012;166(5):1023-34
Scola N, Gambichler T, Saklaoui H, Bechara FG, Georgas D, Stücker M, Gläser R, Kreuter A.
The expression of antimicrobial peptides is significantly altered in cutaneous squamous cell carcinoma and precursor lesions.
Br J Dermatol 2012;167:591-7
Denton CP, Krieg T, Guillevin L, Schwierin B, Rosenberg D, Silkey M, Zultak M, Matucci-Cerinic M, DUO Registry investigators
Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry.
Ann Rheum Dis 2012;71(5):718-721


Laudien M, Dressel S, Harder J, Gläser R
Differential expression pattern of antimicrobial peptides in nasal mucosa and secretion
Rhinology 2011;49(1):107-11
Meyer- Hoffert U, Zimmermann A, Czapp M, Bartels J, Koblyakova Y, Gläser R, Schröder JM, Gerstel U
Flagellin Delivery by Pseudomonas aeruginosa Rhamnolipids Induces the Antimicrobial Protein Psoriasin in Human Skin.
PLoS One 2011;25;6(1): e16433
Gläser R
Helping patients quit smoking: A role for the dermatologist?
Hautarzt 2011;62(2):156-158
Gläser R, Meyer-Hoffert U, Harder J
Fortschritte der praktischen Dermatologie und Venerologie 2010 (Hrsg.Ruzicka, Th.; Wolff, H.; Thomas, P.; Prinz) 2011;S 242-246
Harder J, Gläser R
Abwehr und Entzündung – Antimikrobielle Proteine als Infektionsschutz
Fortschritte der praktischen Dermatologie und Venerologie 2010 (Hrsg.Ruzicka, Th.; Wolff, H.; Thomas, P.; Prinz, J.) 2011;S 531-542
Kreuter A, Jaouhar M, Skrygan M, Tigges C, Stücker M, Altmeyer P, Gläser R, Gambichler T
Expression of antimicrobial peptides in different subtypes of cutanous lupus erythematosus
J Am Acad Dermatol 2011;Epub Jan 27
Gläser R, Köten B, Wittersheim M, Harder J
Psoriasin: key molecule of the cutaneous barrier?
J Dtsch Dermatol Ges 2011;Epub Apr 19
Garreis F, Gottschalt M, Schlorf T, Gläser R, Harder J, Worlitzsch D, Paulsen FP
Expression and regulation of antimicrobial peptide psoriasin (S100A7) at the ocular surface and in the lacrimal apparatus
Invest Ophthalmol Vis Sci 2011;Epub May 6
Dombrowski Y, Peric M, Koglin S, Kammerbauer C, Göß C, Anz D, Simanski M, Gläser R, Harder J, Hornung V, Gallo RL, Ruzicka T, Besch R, Schauber J
Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions
Sci Transl Med 2011;Epub May 11
Kuhn A, Wozniacka A, Szepietowski JC, Gläser R, Lehmann P, Haust M, Sysa-Jedrzejowska A, Reich A, Oke V, Hügel R, Calderon C, de Vries DE, Nyberg F
Photoprovocation in Cutaneous Lupus Erythematosus: A Multicenter Study Evaluating a Standardized Protocol
J Invest Dermatol 2011;Epub May 19
Gläser R
Research in practice: Antimicrobial peptides of the skin
J Dtsch Dermatol Ges 2011;Epub May 19
Jensen JM, Ahrens K, Mengassner J, Scherer A, Bräutigam M, Stütz A, Schwarz T, Fölster-Holst R, Harder J, Gläser R, Proksch E
Differential suppression of epidermal antimicrobial protein expression in atopic dermatitis and in EFAD mice by pimecrolimus compared to corticosteroids
Exp Dermatol 2011;Epub June 24
Westermann L, Hügel R, Meier M, Zillikens D, Gläser R, Schmidt E
Glucocorticosteroid-resistant pemphigoid gestationis: a therapeutic challenge using protein A immunoadsorbtion
J Dermatol 2011;Ahead of print
Meyer-Hoffert U, Zimmermann A, Czapp M, Gläser R, Kobliakova J, Schröder JM, Gerstel U
Rhamnolipids from Pseudomonas aeruginosa enable flagellin induction of antimicrobial psoriasin expression in human skin
PLoS ONE 2011;6:e16433
Brasch J, Beck-Jendroschek V, Gläser R.
Fast and sensitive detection of Trichophyton rubrum in superficial tinea and onychomycosis by use of a direct polymerase chain reaction assay.
Mycoses 2011;54(5):313-7


Meyer-Hoffert U, Schröder JM, Schwarz T, Gläser R
Increased Expression of human beta-Defensin 3 in Mollusca contagiosa
Clin Exp Dermatol 2010;35:190-192
Dressel s, Harder J, Cordes J, Wittersheim M, Meyer-Hoffert U, Sunderkötter C, Gläser R
Differential expression of antimicrobial peptides in margins of chronic wounds
Exp Dermatol 2010;Exp Dermatol 19(7):628-32
Harder J, Dressel S, Wittersheim M, Cordes J, Meyer-Hoffert U, Mrowietz U, Fölster-Holst R, Proksch E, Schröder JM, Schwarz T, Gläser R
Enhanced expression an secretion of antimicrobial peptides in atopic dermatitis an after superficial skin injury
J Invest Dermatol 2010;130(5):1355-64
Gläser R
Cutaneous leiomyomas. A key to the early recognition of malignant renal tumorts?
Hautarzt  2010;3:265-6
Mildner M, Stichenwirth M, Abtin A, Eckhart L, Sam C, Gläser R, Schröder JM, Gmeiner R, Mlitz V, Pammer J, Geusau A, Tschachler E.
Psoriasin (S100A7) is a major Escherichia coli-cidal factor of the female genital tract.
Mucosal Immunol. 2010;3(6):602-9
Abtin A, Eckhart L, Gläser R, Gmeiner R, Mildner M, Tschachler E.
The Antimicrobial Heterodimer S100A8/S100A9 (Calprotectin) Is Upregulated by Bacterial Flagellin in Human Epidermal Keratinocytes.
J Invest Dermatol. 2010;130(10):2423-30
Brasch J, Beck-Jendroschek V, Gläser R.
Fast and sensitive detection of Trichophyton rubrum in superficial tinea and onychomycosis by use of a direct polymerase chain reaction assay.
Mycoses 2010;Epub May 19
Simanski M, Dressel S, Gläser R, Harder J.
RNase 7 Protects Healthy Skin from Staphylococcus aureus Colonization.
J Invest Dermatol. 2010;130(12):2836-8
Meyer-Hoffert U, Wu Z, Kantyka T, Fischer J, Latendorf T, Hansmann B, Bartels J, He Y, Gläser R, Schröder JM.
Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases.
J Biol Chem 2010;285(42):32174-81


Gläser R, Meyer-Hoffert U, Harder J, Cordes J, Wittersheim M, Kobliakova J, Fölster-Holst R, Proksch E, Schröder JM, Schwarz T
The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption.
J Invest Dermatol. 2009;129(3):641-9
Wu Z, Meyer-Hoffert U, Reithmayer K, Paus R, Hansmann B, He Y, Bartels J, Gläser R, Harder J, Schröder JM.
Highly Complex Peptide Aggregates of the S100 Fused-Type Protein Hornerin Are Present in Human Skin.
J Invest Dermatol 2009;129(6):1446-58
Kantyka T, Latendorf T, Wiedow O, Bartels J, Gläser R, Dubin G, Schröder JM, Potempa J, Meyer-Hoffert U.
Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage.
BIOL CHEM 2009;390(12): 1313-1320
Dressel S, Harder J, Gläser R
Antimikrobielle Peptide der Haut
Haut 2009;6: 223-225
Gambichler T, Skrygan M, Tigges C, Kobus S, Gläser R, Kreuter A.
Significant upregulation of antimicrobial peptides and proteins in lichen sclerosus.
Brit J Dermatol 2009;161(5): 1136-1142
Gläser R, Meyer-Hoffert U, Harder J.
Antimicrobial peptides in atopic dermatitis. A paradigm shift?
Hautarzt 2009;60(9):761-2
Gläser R*, Navid F*, Schuller W, Jantschitsch C, Harder J, Schröder JM, Schwarz A, Schwarz T.
UV-B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo.
J Allergy Clin Immunol 2009;123(5):1117-23
Reithmayer K, Meyer KC, Kleditzsch P, Tiede S, Uppalapati SK, Gläser R, Harder J, Schröder JM, Paus R
Human hair follicle epithelium has an antimicrobial defence system that includes the inducible antimicrobial peptide psoriasin (S100A7) and RNase 7.
BRIT J DERMATOL. 2009;161(1):78-89
Wu Z, Hansmann B, Meyer-Hoffert U, Gläser R, Schröder JM.
Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family.
PLoS One 2009;4(4):e5227
Köten B, Simanski M, Gläser R, Podschun R, Schröder JM, Harder J.
RNase 7 contributes to the cutaneous defense against Enterococcus faecium.
PLoS One. 2009;4(7):e6424.


Meyer-Hoffert U, Schwarz T, Schröder JM, Gläser R
Expression of human beta-defensin-2 and -3 in verrucae vulgares and condylomata acuminata.
J Eur Acad Dermatol Venereol. 2008;22(9):1050-4
Meyer JE, Harder J*, Sipos B, Maune S, Klöppel G, Bartels J, Schröder JM, Gläser R       *Co-Erstautor
Psoriasin (S100A7) is a principal antimicrobial peptide of the human tongue.
Mucosal Immunol 2008;1(3):239-243.
Domm S, Gläser R, Mrowietz U
Systemische Therapie in der Dermatologie. Ein praktischer Ratgeber zur Verordnung, Anwendung und Therapieüberwachung
Karger Verlag 2008;


Moubayed N, Weichenthal M, Harder J, Wandel E, Sticherling M, Glaser R
Psoriasin (S100A7) is significantly up-regulated in human epithelial skin tumours
J Cancer Res Clin Oncol 2007;133(4):253-61
Hügel R, Schwarz T, Gläser R.
Resistance to hydroxychloroquine due to smoking in a patient with lupus erythematosus tumidus.
Br J Dermatol 2007;157(5):1081-3
Harder J, Gläser R, Schröder JM.
The role and potential therapeutical applications of antimicrobial proteins in infectious and inflammatory diseases.
Endocr Metab Immune Disord Drug Targets 2007;7(2):75-82.
Harder J, Gläser R, Schröder JM
Human antimicrobial proteins effectors of innate immunity.
J Endotoxin Res. 2007;13(6): 317-38
Gläser R, Harder J, Schröder JM
Antimicrobial Peptides as First-Line Effector Molecules of the Human Innate Immune System.
Nucleic Acids and Molecular Biology 2007;21:187-218
Schroeder JM, Glaeser R, Harder J
Antimicrobial Peptides: Effector molecules of the cutaneus defense system.
In: Molecular Biology and Pharmacology of Tissue Repair, ed. S. Werner, International Congress Series 1302. 2007;26-35
Gläser R, Harder J, Schröder J-M
Antimicrobial Peptides as First-Line Effector Molecules of the Human Innate Immune System.
In: Innate Immunity of Plants, Animals and Humans. Eds.: H.Heine, Springer Verlag Berlin Heidelberg New York . 2007;Chapter 9: 187-218


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Gläser R, Harder J, Lange H, Bartels J, Christophers E, Schröder JM
Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection


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Gläser R
Psoriasis am behaarten Kopf
Aktuelle Dermatologie  2003;29:521-523
Treumer F, Zhu K, Glaser R, Mrowietz U
Dimethylfumarate is a potent inducer of apoptosis in human T cells.
Mrowietz U, Gläser R
Report of the 9th Psoriasis Specialty Congress, Bad Bentheim, 5 April 2003
HAUTARZT  2003;54-1131-1134
Hauschild A, Gläser R
Malignes Melanom.
In: Klinikleitfaden Dermatologie, 2. Auflage, Urban und Fischer (München). 2003;
Gläser, R
Kopfhautpsoriasis und Nagelpsoriasis.
In: Christophers E., Mrowietz U, Sterry W (Hg) Psoriasis, auf einen Blick (2. aktualisierte Auflage)Berlin Blackwell Verlag. 2003;


Bock, O., Mrowietz, U., Gläser, R.
Schwärzliche Hyperpigmentierungen bei 3 Patienten.
HAUTARZT 2002;53:416-420
Gläser, R., Sticherling, M.
Successful treatment of Linear Immunoglobulin A Bullous Dermatosis with Mucophenolat Mofetil.
Gläser, R.
Derm and Crime.
HAUTARZT 2002;53:781-782
Zhu, K., Gläser, R., Mrowietz, U.
Vitamin D3 and analogues modulate the expression of CSF-1 and its receptor in human dendritic cells.
Gläser, R.
In: Christophers, Mrowietz, Sterry (Hrsg.): Psoriasis auf einen Blick. 2002;
Gläser, R.
In: Christophers, Mrowietz, Sterry (Hrsg.): Psoriasis auf einen Blick. 2002;




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