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Sommer A, Düppe M, Baumecker L, Kordowski F, Büch J, Fuchslocher Chico J, Fritsch J, Schütze S, Adam D, Sperrhacke M, Bhakdi S, Reiss K
Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding. Oncotraget 2017. [in press]

Reiss K, Bhakdi S
The plasma membrane: Penultimate regulator of ADAM sheddase function. Biochim Biophys Acta. 2017 Nov;1864(11 Pt B):2082-2087.

Maretzky T, Swendeman S, Mogollon E, Weskamp G, Sahin U, Reiss K, Blobel CP
Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays. Biochem J. 2017 Apr 13;474(9):1467-1479.

Mohanty T, Alberius P, Schmidtchen A, Reiss K, Schröder JM, Sørensen OE
Saliva induces expression of antimicrobial peptides and promotes intracellular killing of bacteria in keratinocytes by EGFR-transactivation. Br J Dermatol. 2017 Feb;176(2):403-412.

Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K.
Phosphatidylserine exposure is required for ADAM17 sheddase function. Nat Commun. 2016 May 10;7:11523. doi: 10.1038/ncomms11523.

Sommer A, Bhakdi S, Reiss K
How membrane asymmetry regulates ADAM17 sheddase function. Cell Cycle.2016 Jul 27:1-2.


Düsterhöft S, Michalek M, Kordowski F, Oldefest M, Sommer A, Röseler J, Reiss K, Grötzinger J, Lorenzen I
Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity. Biochemistry. 2015 Sep 29;54(38):5791-801.


Speck N, Brandsch C, Schmidt N, Yazdekhasti N, Hirche F, Lucius R, Rimbach G, Stangl GI, Reiss K

The Antiatherogenic Effect of Fish Oil in Male Mice Is Associated with a Diminished Release of Endothelial ADAM17 and ADAM10 Substrates. J Nutr. 2015 Jun;145(6):1218-26.


Maretzky T, Evers A, Le Gall S, Alabi RO, Speck N, Reiss K, Blobel CP 
The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding. J Biol Chem. 2015 Mar 20;290(12):7416-25.


Pigholdt S, Pallauf K, Esatmeyoglu T, Speck N, Reiss K, Ruddigkeit L, Stocker A, Huebbe P, Rimbach G

Biochanin A and prunetin improve epithlial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-KB and tyrosine phospohorylation. Free Radic Biol Med. 2014 May; 70:255-64.


Groot AJ, Habets R, Yahyanejed S, Hodin CM, Reiss K, Saftig P, Theys J, Vooijs M

Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins. Mol Cell Biol. 2014 Aug; 34(15):2882-32.


Dasari P, Fries A, Heber SD, Salama A, Blau IW, Lingelbach K, Bhakdi SC, Udomsangpetch R, Torzewski M, Reiss K, Bhakdi S

Malarial anemia: digestive vacuole of Plasmodium falciparum mediates complement deposition on bystander cells to provoke hemophagocytosis. Med Microbiol Immunol. 2014, 203(6):383-93.


Dewitz C, Möller-Hackbarth K, Schweigert O, Reiss K, Chalaris A, Scheller J, Rose-John S  

T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding. FEBS J. 2014 Jan;281(1):157-74.


Sperrhacke M, Fischer J, Wu Z, Klünder S, Sedlacek R, Schroeder JM, Meyer-Hoffert U, Reiss K

SPINK9 Stimulates Metalloprotease/EGFR-Dependent Keratinocyte Migration via Purinergic Receptor Activation. J Invest Dermatol. 2014 Jun;134(6):1645-1654.

Fischer J, Wu Z, Kantyka T, Sperrhacke M, Dimitrieva O, Koblyakova Y, Ahrens K, Graumann N, Baurecht H, Reiss K, Schröder JM, Proksch E, Meyer-Hoffert U

Characterization of Spink6 in Mouse Skin: The Conserved Inhibitor of Kallikrein-Related Peptidases Is Reduced by Barrier Injury. J Invest Dermatol. 2014 May; 134(5):1305-12.


Tharmarajah G, Faas L, Reiss K, Saftig P, Young A, Van Raamsdonk CD

Adam10 haploinsufficiency causes freckle-like macules in Hairless mice. Pigment Cell Melanoma Res. 2012 Sep 25(5):555-65.


Reiss K, Bhakdi S

Pore-forming bacterial toxins and antimicrobial peptides as modulators of ADAM function. Med Microbiol Immunol. 2012 Nov 201(4):419-26.


Sommer A, Fries A, Cornelsen I, Speck N, Koch-Nolte F, Gimpl G, Andrae J, Bhakdi S, Reiss K

Mellitin Modulates keratinocyte function through P2-receptor-dependent ADAM activation. J Biol Chem. 2012 Jul 6;287(28):23678-89.


Dasari P, Heber SD, Beisele M, Torzewski M, Reifenberg K, Orning C, Fries A, Zapf AL, Baumeister S, Lingelbach K, Udomsangpetch R, Bhakdi SC, Reiss K, Bhakdi S

Digestive vacuole of Plasmodium falciparum released during erythrocyte rupture dually activates complement and coagulation. Blood. 2012 May 3:119(8):4301-10.


Dasari P, Reiss K, Lingelbach K, Baumeister S, Lucius R, Udomsangpetch R, Bhakdi S C, Bhakdi S (2011)

Digestive valuoles of Plamodium falciparum are selectively phagocytodes by and impair killing function of polymorphonuclear leukocytes. Blood. 118, 4946-4956.


Reiss K, Meyer-Hoffert U, Fischer J, Sperrhacke M, Wu Z, Dimitrieva O, Krenek P, Suchanove S, Buryova H, Brauer R, Sedlacek R (2011)

Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2. Exp Dermatol. 20:905-10.


Kantyka T, Fischer J, Wu Z, Declercq W, Reiss K, Schröder JM, Meyer-Hoffert U (2011)

Inhibition of Kallikrein-related Peptidases by the Serine Protease Inhibitor of Kazal-type 6. Peptides. 32,1187-1192.


Reiss K, Cornelsen I, Husmann M, Gimpl G, Bhakdi S (2011)

Unsaturated Fatty Acids Drive Disintegrin and Metalloproteinase (ADAM)-dependent Cell Adhesion, Proliferation and Migration by Modulationg Membrame Fluidity. J BiolChem. 286, 26931-26942.


Maretzky T*, Evers A*, Zhou W, Wong PM, Reiss K, Blobel CP (2011)

FGF7-stimulated epithelial cell migration requires transactivation of EGFR signaling by ADAM17. Nature Communications. 2:229. 

Jung S, Mysliwy J, Spudy B, Lorenzen I, Reiss K, Gelhaus C, Podschun R, Leippe M, Grötzinger J (2011)

Human β-Defensin 2 and {beta}-Defensin 3 Chimeric Peptides Reveal the Structural Basis of the Pathogen Specificity of Their Parent Molecules. Antimicrob Agents Chemother. 55:954-60.


Pahl R, Brunke G, Steubesand N, Schubert S, Böttner M, Wedel T, Jürgensen C, Hampe J, Schäfer H, Zeissig S, Schreiber S, Rosenstiel P, Reiss K, Arlt A (2011)

IL-1β and ADAM17 are central regulators of {beta}-defensin expression in Candida esophagitis. Am J Physiol Gastrointest Liver Physiol. 2011 Apr;300(4):G547-53.

Saftig P and Reiss K (2011)

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential? European Journal Cell Biol. 90,527-535.


Le Gall SM, Maretzky T, Issuree PDA, Niu XD, Reiss K, Saftig P, Khokha R, Lundell D, Blobel CP (2010)

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site. J Cell Sci. 123:3913-22.


Jung S, Mysliwy J, Spudy B, Lorenzen I, Reiss K, Gelhaus C, Podschun R, Leippe M, Grötzinger J (2010)

Human β-defensin2 and β-defensin3 chimeric peptides reveal the structural basis of the pathogen specificity of their parent molecules. Antimicrob Agents Chemother. 2010 Dec 28.


Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S (2010)

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med. 207:1617-24.


Müller M, Beck IM, Gadesmann J, Karschuk N, Paschen A, Proksch E, Djonov V, Reiss K, Sedlacek R (2010)

MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells. Mod Pathol. 23:511-21.


Foveau B, Ancot F, Leroy C, Petrelli A, Reiss K, Vingtdeux V, Giordano S, Fafeur V, Tulasne D (2009)

Downregulation of the Met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis. Mol Biol Cell. 2009 May;20(9):2495-507.


Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss K, Maes E, Snellinx A, Serneels L, Nyabi O, Annaert W, Saftig P, Hartmann D, De Strooper B (2009)

ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Noch and other proteins, is processed by ADAMs9,-15, and the Gamma Secreates. J Biol Chem. 2009 Apr 24;284(17):11738-47.


Le Gall S, Bobé P, Reiss K, Horiuchi K, Niu XD, Lundell D, Gibb DR, Conrad D, Saftig P, Blobel CP (2009)

ADAMs 10 and 17 are differentially regulated components of the sheddingmachinery for TGFα, TNFα and other membrane proteins. Mol Biol Cell. 2009 Mar;20(6):1785-94. 


Koenen RR, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, Reiss K, Sarabi A, Lindbom L, Hackeng TM, Weber C, Ludwig A (2009)

Regulated shedding of the junctional adhesion molecule JAM-A by the disintegrin and metalloproteinase ADAM17 controls neutrophil recruitment. Blood. 2009 May 7;113(19):4799-809. 


Liu Q, Zhang J, Tran H, Verbeek MM, Reiss K, Estus S (2009)

LRP1 shedding in human brain: roles of ADAM10 and ADAM17. Mol Neurodegener. 4:17


Huth T, Schmidt-Neuenfeldt K, Rittger A, Saftig P, Reiss K, Alzheimer C (2009)

Non-proteolytic effect of beta-site APP-cleaving enzyme 1 (BACE1) on sodium channel function. Neurobiol Dis. 33:282-9.


Reiss K and Saftig P  (2009)

The “A Disintegrin And Metalloprotease” (ADAM) family of Sheddases: Physiological and Cellular Functions. Semin Cell Dev Biol. 20:126-137.


Deuss M, Reiss K, Hartmann D (2008)

Part time alpha-secretases: the functional biology of ADAM9, 10 and 17. Curr. Alz. Res. 5:187-201.


Raucci A, Cugusi S, Antonelli A, Barabino SM, Monti L, Bierhaus A, Reiss K, Saftig P, Bianchi ME (2008)

A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10). FASEB J. 2008;22:3716-27.


Schulz B, Pruessmeyer J, Maretzky T, Ludwig A, Blobel C, Saftig P, Reiss K (2008)

Disintegrin Metalloprotease (ADAM) 10 Regulates Endothelial Permeability and T Cell Transmigration by Proteolysis of Vascular Endothelial Cadherin. Circ Res. 102:1192-201.


Maretzky T, Scholz F, Rudolph B, Proksch E, Saftig P, Reiss K (2008)

The disintegrin-metalloproteinase 10 plays a key role for regulating keratinocyte cohesion in eczematous dermatitis. J Invest Dermatol. 128:1737-46.


Martin L, Fluhrer R, Reiss K, Saftig P, Haass C (2007)

Regulated Intramembrane Proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/b. J Biol Chem. 283:1644-52.


Hundhausen C, Schulte A, Schulz B, von Hundelshausen P, Achilles J, Winter U, Paliga K, Reiss K, Saftig P, Weber C, Ludwig A (2007)

Regulated shedding of transmembrane chemokines by the metalloproteinase ADAM10 facilitates detachment of adherent leukocytes. J Immunology. 178: 8064-72.


Schulte A, Schulz B, Andrzejewski M G, Hundhausen C, Mletzko S, Achilles J, Reiss K, Paliga K, Weber C, Rose J S, Ludwig A (2007).

Sequential processing of the transmembrane chemokines CX3CL1 and CXCL16 by alpha- and gamma-secretases. Biochem Bioph Res Co. 358: 233-240.


Schulte M, Reiss K*, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P (2007)

ADAM10 modulates FasL-induced cytotoxicity and activation-induced cell death of T lymphocytes. Cell Death Differ. 14:1040 – 1049.


Horiuchi K, Le Gall S, Schulte M, Yamaguchi T, Reiss K, Murphy G, Toyama Y, Hartmann D, Saftig P, Blobel CP (2007)

Substrate Selectivity and Regulation of EGF-Receptor Ligand Sheddases by Phorbol Esters and Calcium Influx. Mol Biol Cell.18: 176-188.


Tousseyn T, Jorissen E, Reiss K, Hartmann D (2006)

(Make) stick and cut loose--disintegrin metalloproteases in development and disease. Birth Defects Res C Embryo Today 78: 24-46.


Reiss K, Ludwig A, Saftig P (2006)

Breaking up the tie: Disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion. Pharmacol Therapeut 111: 985-1006.


Reiss K, Maretzky T*, Haas IG, Schulte M, Ludwig A, Frank M, Saftig P (2006)

Regulated ADAM10-dependent Ectodomain Shedding of {gamma}-Protocadherin C3 Modulates Cell-Cell Adhesion. J Biol Chem 281: 21735-21744.


D'Hooge R, Lullmann-Rauch R, Beckers T, Balschun D, Schwake M, Reiss K, von Figura K, Saftig P (2005)

Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis. J Neurosci 25: 6539-6549.


Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, Moechars D, Alzheimer C, Reiss K, Saftig P, De Strooper B (2005)

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem 280: 30797-30806.


Ludwig A, Schulte A, Schnack C, Hundhausen C, Reiss K, Brodway N, Held-Feindt J, Mentlein R (2005)

Enhanced expression and shedding of the transmembrane chemokine CXCL16 by reactive astrocytes and glioma cells. J Neurochem 93: 1293-1303.


Maretzky T, Reiss K*, Ludwig A, Buchholz J, Scholz F, Proksch E, De Strooper B, Hartmann D, Saftig P (2005)

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. P Natl Acad Sci U S A 102: 9182-9187.


Maretzky T, Schulte M, Ludwig A, Rose-John S, Blobel C, Hartmann D, Altevogt P, Saftig P, Reiss K (2005)

L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth. Mol Cell Biol 25:9040-9053.


Reiss K, Maretzky T*, Ludwig A, Tousseyn T, De Strooper B, Hartmann D, Saftig P (2005)

ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling. EMBO J 24: 742-752.


Suttmann H, Jacobsen M, Reiss K, Jocham D, Bohle A, Brandau S (2004)

Mechanisms of bacillus Calmette-Guerin mediated natural killer cell activation. J Urology 172: 1490-1495.


Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C (2004)

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzymeJ Biol Chem279:53205-53212.


Gamp AC, Tanaka Y, Lullmann-Rauch R, Wittke D, D'Hooge R, De Deyn PP, Moser T, Maier H, Hartmann D, Reiss K, Illert AL, von Figura K, Saftig P (2003)

LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice. Hum Mol Genet 12:631-646.


Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A (2003)

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood 102: 1186-1195.


Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B (2003)

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. J Biol Chem 278: 48713-48719.


Reiss K, Mentlein R, Sievers J, Hartmann D (2002)

Stromal cell-derived factor 1 is secreted by meningeal cells and acts as chemotactic factor on neuronal stem cells of the cerebellar external granular layer. Neuroscience 115: 295-305.



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