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Prof. Dr. Jürgen Harder - Scientific (peer reviewed) publications

 

> 14.500 cumulative citations (Google Scholar Citations)

h-index: 51 (Google Scholar Citations)

 

Original publications

  

Tiedemann R, Harder J, Gmeiner C, Haase E (1996) Mitochondrial DNA sequence patterns of harbour porpoises (Phocoena phocoena) from the North and the Baltic sea. International Journal of Mammalian Biology 61(2): 104-111

Harder J, Bartels J, Christophers E, Schröder JM (1997) A peptide antibiotic from human skin. Nature 387: 861.

Harder J, Siebert R, Zhang Y, Matthiesen P, Christophers E, Schlegelberger B, Schröder JM (1997) Mapping of the gene encoding human beta-defensin-2 (DEFB2) to chromosome region 8p22-p23.1 Genomics 46: 472-475.

Retz M, Lehmann J, Roder C, Plotz B, Harder J, Eggers J, Pauluschke J, Kalthoff H, Stöckle M (1998) Differential mucin MUC7 gene expression in invasive bladder carcinoma in contrast to uniform MUC1 and MUC2 gene expression in both normal urothelium and bladder carcinoma. Cancer Research 58(24):5662-5666.

Wiedow O, Harder J, Bartels J, Streit V, Christophers E (1998) Antileukoprotease in human skin: an antibiotic peptide constitutively produced by keratinocytes. Biochemical and Biophysical Research Communications 248: 904-909.

Harder J, Meyer-Hoffert U, Teran L M, Schwichtenberg L, Bartels J, Maune S, Schröder JM (2000) Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. American Journal of Respiratory Cell and Molecular Biology 22:714-721. 

Meyer JE, Harder J, Gorögh T, Schröder JM, Maune S (2000) hBD-2 gene expression in nasal mucosa. Laryngorhinootologie 79: 400-403.

Harder J, Bartels, J, Christophers, E, Schröder, JM (2001) Isolation and characterization of Human Beta-Defensin-3, a novel human inducible peptide antibiotic. Journal of Biological Chemistry 276: 5570-5713.

Dunsche A, Acil Y, Siebert R, Harder J, Schröder JM, Jepsen S (2001) Expression profile of human defensins and antimicrobial proteins in oral tissues. Journal of Oral Pathology & Medicine 30: 154-158.   

Harder J, Schröder, JM (2002) RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. Journal of Biological Chemistry 277: 46779- 46784.

Lehmann J, Retz M, Harder J, Krams M, Kellner U, Hartmann J, Hohgrawe K, Raffenberg U, Gerber M, Loch T, Weichert-Jacobsen K, Stöckle M (2002) Expression of human beta-defensins 1 and 2 in kidneys with chronic bacterial infection. BMC Infect Dis 18, 2(1):20.

Sahly H, Schubert S, Harder J, Rautenberg P, Ullmann U, Schröder JM Podschun R (2003) The genus Burkholderia is highly resistant against human beta-defensin 3 (hBD-3) Antimicrobial Agents and Chemotherapy  47(5):1739-1741.

Wehkamp J, Harder J, Weichenthal M, Müller O, Herrlinger KR, Fellermann K, Schröder JM Stange EF (2003) Inducible and constitutive beta-defensins are differentially expressed in inflammatory bowel diseases. Inflammatory  Bowel Disease 9:215-223.

Harder J, Meyer-Hoffert U, Wehkamp K, Schwichtenberg L, Schröder JM (2004) Differential Gene Induction of Human ß-Defensins (hBD-1, -2, -3 and -4) in Keratinocytes is Inhibited by Retinoic Acid. Journal of Investigative Dermatology 123(3):522-529.

Meyer JE, Harder J, Görögh T, Weise JB, Schubert S, Janssen D, Maune S (2004) hBD-2 in oral cancer with opportunistic Candida infection. Anticancer Research 24(2B):1025-1030.

Varoga D, Pufe T, Harder J, Meyer-Hoffert U, Mentlein R, Schröder JM, Petersen WJ,  Tillmann BN, Proksch E, Goldring MB, Paulsen FP (2004) Production of endogenous antibiotics in articular cartilage. Arthritis & Rheumatism 50:3526-3534.

Wehkamp J, Harder J, Wehkamp K, Wehkamp-von Meissner B, Schlee M, Enders C, Sonnenborn U, Nuding S, Bengmark S, Fellermann K, Schröder JM, Stange EF (2004) NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Infection and Immunity 72(10):5750-5758.

Wehkamp J, Harder J*, Weichenthal M, Schwab M, Schäffeler E, Schlee M, Herrlinger KR, Stallmach A, Noack F, Fritz P, Schröder JM, Bevins CL, Fellermann K, Stange EF (2004) NOD2 (CARD15) mutations in Crohn´s disease are associated with diminished mucosal α-defensin expression. Gut 53:1658 – 1664.  *co-first author

Gläser R, Harder J*, Lange H, Bartels J, Christophers E, Schröder JM (2005) Antimicrobial Psoriasin (S100A7) protects human skin from E coli infection. Nature Immunology 6(1):57-64. *co-first author

Varoga D, Pufe T, Harder J, Schröder JM, Meyer-Hoffert U, Mentlein R, Tillmann BN, Goldring MB, Paulsen FP (2005) Human beta-defensin-3 mediates tissue remodeling processes in articular cartilage by increasing metalloproteinases and reducing their endogenous inhibitors. Arthritis & Rheumatism 52(6):1736-1745.

Kiehne K, Brunke G, Meyer D, Harder J, Herzig KH (2005) Oesophageal defensin expression during Candida infection and reflux disease. Scandinavian Journal of Gastroenterology 40(5):501-507.  

Wehkamp K, Schwichtenberg L, Schröder JM, Harder J (2006) Pseudomonas aeruginosa- and IL-1ß-mediated induction of human beta-defensin-2 (hBD-2) in keratinocytes is controlled by NF-κB and AP-1. Journal of Investigative Dermatology 126(1):121-127.

Voss E, Wehkamp J, Wehkamp K, Stange EF, Schröder JM, Harder J (2006) NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. Journal of Biological Chemistry 281(4):2005-2011.

Sahly H, Schubert S, Harder J, Kleine M, Sandvang D, Ullmann U, Schröder JM, Podschun R (2006) Activity of human beta-defensins 2 and 3 against ESBL-producing Klebsiella strains. Journal of Antimicrobial Chemotherapy 57(3):562-565.

Lehmann J, Retz M, Sidhu SS, Sell M, Paulsen F, Harder J, Unteregger G, Stöckle M (2006) Antitumor Activity of the Antimicrobial Peptide Magainin II against Bladder Cancer Cell Lines. European Urology  50(1):141-147.

Böhling A, Hagge SO, Roes S, Podschun R, Sahly H, Harder J, Schröder JM, Grötzinger J, Seydel U, Gutsmann T (2006) Lipid-specific membrane activity of human beta-defensin-3. Biochemistry 45(17):5663-5670.

Rudolph B, Podschun R, Sahly H, Schubert S, Schröder JM, Harder J (2006) Identification of RNase 8 as a novel human antimicrobial protein. Antimicrobial Agents and Chemotherapy 50(9):3194-3196.

Moubayed N, Weichenthal M, Harder J, Wandel E, Sticherling M, Gläser R (2007) Psoriasin (S100A7) is significantly upregulated in human epithelial skin tumours. Journal of Cancer Research and Clinical Oncology 133(4):253-261.

Schlee M, Harder J, Köten B, Stange EF, Wehkamp J, Fellermann K (2008) Probiotic lactobacilli and VSL#3 induce enterocyte ß-defensin 2. Clinical & Experimental Immunology 151(3):528-535.

Meyer JE, Harder J*, Sipos B, Maune S, Klöppel G, Bartels J, Schröder JM, Gläser R (2008) Psoriasin (S100A7) is a principal antimicrobial peptide of the human tongue. Mucosal Immunology, 1: 239 – 243. *co-first author

Hinrichsen K, Podschun R, Schubert S, Schröder JM, Harder J*, Proksch E (2008) Mouse beta-defensin-14 (mBD-14/defb14): An antimicrobial ortholog of human beta-defensin-3 (hBD-3/DEFB103A), Antimicrobial Agents and Chemotherapy, 52(5):1876-1879. *co-senior and corresponding author

Suttmann H, Retz M, Paulsen F, Harder J, Zwergel U, Kamradt J, Wullich B, Unteregger G, Stöckle M, Lehmann J (2008) Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells. BMC Urology, 8:5.

Eigenbrod T, Park JH, Harder J, Iwakura Y, Nunez G (2008) Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1a 181(12) Released from Dying Cells, Journal of Immunology, 181(12): 8194-8198.

Bosch T, Zill H, Augustin R, Hemmrich G, Kremling S, Rölk C, Anton-Erxleben F, Leippe M, Stanisak M, Grötzinger J, Jung S, Podschun R, Bartels J, Harder J, Jens-M. Schröder (2009) Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Developmental & Comparative Immunology  3(4):559-569.

Gläser R, Meyer-Hoffert U, Harder J, Cordes J, Wittersheim M, Kobliakova J, Fölster-Holst R, Proksch E, Schröder JM, Schwarz T (2009) The Antimicrobial Protein Psoriasin (S100A7) Is Upregulated in Atopic Dermatitis and after Experimental Skin Barrier Disruption. Journal of Investigative Dermatology 129(3):641-649.

Wu Z, Meyer-Hoffert U, Reithmayer K, Paus R, Hansmann B, He Y, Bartels J, Gläser R , Harder J, Schröder JM (2009) Highly complex Peptide Aggregates of the S100 Fused-Type Protein Hornerin are Present in Human Skin. Journal of Investigative Dermatology 129(6):1446-1458.

Harder J and Nunez G (2009) Functional expression of the intracellular pattern recognition receptor NOD1 in human keratinocytes. Journal of Investigative Dermatology 129(5): 1299:1302.

Gläser R, Navid F, Schuller W, Jantschitsch C, Harder J, Schröder J, Schwarz A, Schwarz T (2009) Ultraviolet B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo. Journal of Allergy and Clinical Immunology  123(5):1117-1123.

Reithmayer K, Meyer K, Harder J, Gläser R, Schröder JM, Paus R (2009) Human hair follicle epithelium displays an antimicrobial defence system that includes the inducible psoriasin (S100A7) and RNase 7. British Journal of Dermatology, 161(1):78-89.

Abtin A, Eckhart L, Mildner M, Ghannadan M, Harder J, Schröder JM, Tschachler E. (2009) Degradation by Stratum Corneum Proteases Prevents Endogenous RNase Inhibitor from Blocking Antimicrobial Activities of RNase 5 and RNase 7. Journal of Investigative Dermatology;129(9):2193-201

Harder J, Franchi L, Munoz-Planillo R, Park JH, Reimer T, Nunez G (2009) Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF-kappaB Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor. Journal of Immunology, 183(9):5823-5829.

Köten B, Gläser R, Podschun R, Schröder JM, Harder J (2009) RNase 7 contributes to the cutaneous defense against Enterococcus faecium. PLoS One, 29;4(7):e6424.

Dressel S, Harder J*, Cordes J, Wittersheim M, Meyer-Hoffert U,  Sunderkötter C, R. Gläser (2010) Differential expression of antimicrobial peptides in margins of chronic  wounds. Experimental Dermatology 19(7):628-632, *co-first author

Harder J, Dressel S, Wittersheim M, Cordes J, Meyer-Hoffert U, Mrowietz U, Fölster-Holst R, Proksch E, Schröder JM, Schwarz T, Gläser R. (2010) Enhanced Expression and Secretion of Antimicrobial Peptides in Atopic Dermatitis and after Superficial Skin Injury. Journal of Investigative Dermatology 130(5):1355-1364.

Himmerkus N, Vassen V, Sievers B, Goerke B, Shan Q, Harder J, Schröder JM, Bleich M (2010) Human beta-defensin-2 increases cholinergic response in colon epithelium. Pflügers Archiv - European Journal of Physiology 460(1):177-186.

Simanski M, Dressel S, Gläser R, Harder J (2010) RNase 7 protects healthy skin from Staphylococcus aureus colonization. Journal of Investigative Dermatology 130(12):2836-2838.

Ahrens K, Schunck M, Podda GF, Meingassner J, Stuetz A, Schröder JM, Harder J, Proksch E (2011) Mechanical and Metabolic Injury to the Skin Barrier Leads to Increased Expression of Murine β-Defensin-1, -3, and -14. Journal of Investigative Dermatology 131(2):443-452.

Laudien M, Dressel S, Harder J, Gläser R (2011) Differential expression pattern of antimicrobial peptides in nasal mucosa and secretion. Rhinology, Mar;49(1):107-111.

Spencer JD, Schwaderer A, DiRosario J, McHugh KM, McGillivary G,  Carpenter A,  Baker P, Harder J, Hains DS (2011) Ribonuclease 7: a potent antimicrobial peptide within the human urinary tract. Kidney International, 80(2):174-180.

Garreis F, Gottschalt M, Schlorf T,  Gläser R, Harder J, Worlitzsch D, Paulsen FP (2011)  Expression and regulation of antimicrobial peptide psoriasin (S100A7) at the ocular surface and in the lacrimal apparatus. Investigative Ophthalmology and Visual Science, 52(7):4914-22

Dombrowski Y, Peric M, Koglin S, Kammerbauer C, Göss C, Anz D, Simanski M, Gläser R, Harder J, Hornung V, Gallo RL, Ruzicka T, Besch R, Schauber J (2011) Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions. Science Translational Medicine 11;3(82):82ra38.

Jensen JM, Ahrens K, Mengassner J, Scherer A, Bräutigam M, Stütz A, Schwarz T, Fölster-Holst R, Harder J, Gläser R, Proksch E (2011) Differential suppression of epidermal antimicrobial protein expression in atopic dermatitis and in EFAD mice by pimecrolimus compared to corticosteroids. Experimental Dermatology 20(10):783-8.

Köten B, Becker K, Podschun R, von Eiff C, Meyer-Hoffert U, Harder J, Gläser R (2012) Susceptibility of Staphylococcus aureus bacteremia strains to different skin-derived antimicrobial proteins. Archives of Dermatological Research 304(8):633-7

Simanski M, Babucke S, Eberl L, Harder J (2012) Paraoxonase 2 acts as a quorum sensing-quenching factor in human keratinocytes. Journal of Investigative Dermatology 132(9):2296-9 

Simanski M, Gläser R, Köten B, Meyer-Hoffert U, Wanner S, Weidenmaier C, Peschel A, Harder J (2013) Staphylococcus aureus subverts cutaneous defense by D-alanylation of teichoic acids. Experimental Dermatology 22(4):294-6.

Simanski M, Rademacher F, Schröder L, Schumacher HM, Gläser R, Harder J (2013) IL-17A and IFN-γ synergistically induce RNase 7 expression via STAT3 in primary keratinocytes. PLOS ONE 2013;8(3):e59531

Wittersheim M, Cordes J, Meyer-Hoffert U, Harder J, Hedderich J, Gläser R (2013) Differential Expression and in vivo Secretion of the Antimicrobial Peptides Psoriasin (S100A7), RNase 7, human beta-Defensin-2 and -3 in Healthy Human Skin. Experimental Dermatology 22(5):364-6

Schuster C, Gläser R, Fiala C, Eppel W, Harder J (2013) Schröder JM, Elbe-Bürger A.Prenatal human skin expresses the antimicrobial peptide RNase 7.  Archives of  Dermatological Research 305(6):545-9

Lichtenberger BM, Gerber PA, Holcmann M, Buhren BA, Amberg N, Smolle V, Schrumpf H, Boelke E, Ansari P, Mackenzie C, Wollenberg A, Kislat A, Fischer JW, Röck K, Harder J, Schröder JM, Homey B, Sibilia M (2013) Epidermal EGFR Controls Cutaneous Host Defense and Prevents Inflammation. Science Translational Medicine 21;5(199):199ra111

Roth SA, Simanski M, Rademacher F, Schröder L, Harder J (2014) The pattern recognition receptor NOD2 mediates Staphylococcus aureus-induced IL‑17C expression in keratinocytes. Journal of Investigative Dermatology 134(2):374-80

Firat YH, Simanski M, Rademacher F, Schröder L, Brasch J, Harder J (2014) Infection of keratinocytes with Trichophyton rubrum induces epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression. PLOS ONE, 9(4):e93941.

Rodríguez E, Baurecht H, Wahn AF, Kretschmer A, Hotze M, Zeilinger S, Klopp N, Illig T, Schramm K, Prokisch H, Gieger C, Harder J, Cifuentes L, Novak N, Weidinger S. (2014) An integrated epigenetic and transcriptomic analysis reveals distinct patterns of DNA methylation associated with atopic dermatitis. Journal of Investigative Dermatology, 134(7):1873-83.  

Gläser R, Becker K, von Eiff C, Meyer-Hoffert U, Harder J (2014) Decreased susceptibility of Staphylococcus aureus small colony variants (SCVs) towards human antimicrobial peptides. Journal of Investigative Dermatology, 134(9):2347-50.  

Steinz K, Schubert S, Harder J, Gerdes S, Mrowietz U, Gläser R (2014) Bacterial soft tissue infection in psoriasis despite induction of epidermal antimicrobial peptide, Experimental Dermatology, 23(11):862-4.

Amatngalim GD, van Wijck Y, de Mooij-Eijk Y, Verhoosel RM, Harder J, Lekkerkerker AN, Janssen RA, Hiemstra PS. (2015) Basal Cells Contribute to Innate Immunity of the Airway Epithelium through Production of the Antimicrobial Protein RNase 7. Journal of Immunology, 194(7):3340-50.

Scharschmidt H, Ellinghaus D, Rodríguez E, Kretschmer A, Baurecht A,  Lipinski S, Meyer-Hoffert U, Harder J, Lieb W, Novak N, Fölster-Holst R, Esparza-Gordillo J, Marenholz I, Ruschendorf F, Hubner N, Reischl E, Waldenberger M, Gieger C, Illig T, Kabesch M, Zhang XJ, Xiao FL, Lee YA, Franke A, Weidinger S (2015) A genome-wide association study reveals two new susceptibility loci for atopic dermatitis. Journal of Allergy and Clinical Immunology, 136(3):802-6.

Bierkarre H, Harder J, Cuthbert R, Emery P, Leuschner I Mrowietz U, Hedderich J, McGonagle D, Gläser R (2016) Differential expression of antimicrobial peptides in psoriasis and psoriatic arthritis as a novel contributory mechanism for skin and joint disease heterogeneity. Scandinavian Journal of Rheumatology 45(3):188-96.

Simanski M, Rademacher F, Schröder L, Gläser R, Harder J. (2016) The Inflammasome and the Epidermal Growth Factor Receptor (EGFR) Are Involved in the Staphylococcus aureus-Mediated Induction of IL-1alpha and IL-1beta in Human Keratinocytes. PLoS One, 11(1):e0147118.

Bayer A, Lammel J, Rademacher F, Gross J, Siggelkow M, Lippross S, Klüter T, Varoga D, Tohidnezhad M, Pufe T, Cremer J, Gläser R, Harder J (2016)  Platelet-released growth factors induce the antimicrobial peptide human beta-defensin-2 in primary keratinocytes. Experimental Dermatology, 25(6):460-5.

Manz J, Rodríguez E, ElSharawy A, Oesau EM, Petersen BS, Baurecht H, Mayr G, Weber S, Harder J, Reischl E, Schwarz A, Novak N, Franke A, Weidinger S (2016) Targeted resequencing and functional testing identifies low-frequency missense variants in the gene encoding GARP as significant contributors to atopic dermatitis risk. Journal of Investigative Dermatology, 136(12):2380-2386.

Rademacher F, Simanski M, Schröder L, Mildner M, Harder J (2017) The role of RNase 7 in innate cutaneous defense against Pseudomonas aeruginosa. Experimental Dermatology, 26(3):227-233.

Bayer A, Lammel J, Tohidnezhad M, Lippross S, Behrendt P, Klüter T, Pufe T, Cremer J, Jahr H, Rademacher F, Gläser R, Harder J (2017) The antimicrobial peptide human beta-defensin-3 is induced by platelet-released growth factors in primary keratinocytes. Mediators of Inflammation, 2017:6157491.

Bayer A, Lammel J, Lippross S, Klüter T, Behrendt, P, Tohidnezhad M, Pufe T, Cremer J, Jahr H, Rademacher F, Gläser R, Harder J (2017) Platelet-released growth factors induce psoriasin in keratinocytes: Implications for the cutaneous barrier. Annals of Anatomy, 213:25-32.

Kopfnagel V, Wagenknecht S, Brand L, Zeitvogel J, Harder J, Hofmann K, Kleine M, Werfel T (2017) RNase 7 downregulates TH2 cytokine production by activated human T-cells. Allergy, 72(11):1694-1703.

Bayer A, Tohidnezhad M, Lammel J, Lippross S, Behrendt P, Klüter T, Pufe T, Cremer J, Jahr H, Rademacher F, Gläser R, Harder J (2017) Platelet-released growth factors induce differentiation of primary keratinocytes. Mediators of Inflammation, 2017:5671615.

Weber C, Fischer J, Redelfs L, Rademacher F, Harder J, Weidinger S, Wu Z, Meyer-Hoffert U (2017) The serine protease inhibitor of Kazal-type 7 (SPINK7) is expressed in human skin. Archives of Dermatological Research, 309(9):767-771.

Walter S, Rademacher F, Kobinger N, Simanski M, Gläser R, Harder J (2017) RNase 7 participates in cutanoues innate control of Corynebacterium amycolatum. Scientific Reports, 7(1):13862.

Bayer A, Tohidnezhad M, Lammel J, Berndt, R, Lippross S, Behrendt P, Klüter T, Pufe T, Jahr H, Cremer J, Rademacher F, Simanski M, Gläser R, Harder J (2018) Platelet-released growth factors inhibit proliferation of primary keratinocytes in vitro, Annals of Anatomy, 215:1-7.

Wagenknecht S, Kopfnagel V, Harder J, Hofmann K, Kleine M, Sodeik B, Werfel T (2018) RNase 7 strongly promotes TLR9-mediated DNA sensing by human plasmacytoid dendritic cells. Journal of Investigative Dermatology, 138(4):872-881.

Simanski M, Erkens AS,  Rademacher F, Harder J (2019) Staphylococcus epidermidis-induced Interleukin-1 Beta and Human Beta-defensin-2 Expression in Human Keratinocytes is Regulated by the Host Molecule A20 (TNFAIP3). Acta Dermato-Venerologica, 99 (2), 181-187.

Rademacher F, Simanski M, Hesse B, Dombrowsky G, Vent N, Gläser R, Harder J (2019) Staphylococcus epidermidis activates aryl hydrocarbon receptor (AhR) signaling in human keratinocytes: Implications for cutaneous defense. Journal of Innate Immunity, 11 (2), 125-135.

Wehkamp U, Wehkamp K, Harder J  (2020) Dysregulated Expression of Antimicrobial Peptides in Skin Lesions of Patients With Cutaneous T-cell Lymphom. Acta Dermato-Venerologica, 100(1):adv00017

Nehls C, Böhling A, Podschun R, Schubert S, Grötzinger J, Schromm A, Fedders H, Leippe M, Harder J, Kaconis Y, Gronow S, Gutsmann T (2020) Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria. Biochim Biophys Acta Biomembr, 1862(8):183273

Kopfnagel V, Dreyer S, Baumert K, Stark M, Harder J, Hofmann K, Kleine M, Buch A, Sodeik B, Werfel T. (2020) RNase 7 Promotes Sensing of Self-DNA by Human Keratinocytes and Activates an Antiviral Immune Response. J Invest Dermatol. 21:S0022-202X(20)30039-7

Bayer A, Wijaya B, Möbus L, Rademacher F, Rodewald M, Tohidnezhad M, Pufe T, Drücke D, Gläser R, Harder J. (2020) Platelet-Released Growth Factors and Platelet-Rich Fibrin Induce Expression of Factors Involved in Extracellular Matrix Organization in Human Keratinocytes. Int J Mol Sci., 21(12):E4404

Bayer A, Höntsch G, Kaschwich M, Dell A, Siggelkow M, Berndt R, Rusch R, Harder J, Gläser R, Cremer J.(2020) Vivostat Platelet-Rich Fibrin® for Complicated or Chronic Wounds - A Pilot Study. Biomedicines, 6;8(8):E276.

 


Reviews

 

Schröder JM, Harder J (1999) Human beta-defensin-2. The International Journal of Biochemistry & Cell Biology  31:645-651.

Harder J, Schröder JM (2005) Psoriatic Scales: A Promising Source for the Isolation of Human Skin-derived Antimicrobial Proteins. Journal of Leukocyte Biology 77(4):476-486.

Harder J, Schröder JM (2005) Antimicrobial peptides in human skin. Chemical Immunology and Allergy 86:22-41.

Schröder JM, Harder J (2006) Innate antimicrobial peptides in the skin. Medicines Sciences (Paris); 22(2):153-157.

Schröder JM, Harder J (2006) Antimicrobial skin peptides and proteins. Cellular and Molecular Life Sciences 63: 469 – 486.

Schröder JM, Harder J (2006) Antimicrobial Peptides in skin disease. Drug Discovery Today: Therapeutic Strategies  3(1): 93-100.

Harder J, Gläser R, Schröder JM (2007) Antimicrobial Peptides: Effector Molecules of the Cutaneous Defense System. International Congress Series 1302:  26-35

Harder J, Gläser R, Schröder JM (2007) The role and potential therapeutical applications of antimicrobial proteins in infectious and inflammatory diseases. Endocrine, Metabolic & Immune Disorders - Drug Targets 7(2):75-82.                      

Meyer JM, Harder J (2007) Antimicrobial Peptides in Oral Cancer. Current Pharmaceutical  Design 13(30): 3119-3130.

Harder J, Gläser R, Schröder JM (2007) Human Antimicrobial Proteins - Effectors of innate immunity, Journal of Endotoxin Research 13(6): 317-338.

Gläser R, Harder J, Schröder JM (2008) Antimicrobial Peptides as First-Line Effector Molecules of the Human Innate Immune System. Nucleic Acids and Molecular Biology 21: 187-218

Harder J (2008) Antimicrobial peptides: Ancient molecules as modern therapeutics? Expert Review of Dermatology, 3(1):1-5.

Harder J, Proksch E (2008) Antimicrobial proteins: Innate effectors of cutaneous defense. Kératin; 15: 15-23.

Dressel S, Harder J, Gläser R (2009) Antimikrobielle Peptide der Haut. Haut 2009;6: 223-225.

Gläser R., Meyer-Hoffert U., Harder J (2009) Antimicrobial peptides in atopic dermatitis – A paradigm shift. Hautarzt, 60(9):761-762.

Harder J, Gläser R (2010) Abwehr und Entzündung - Antimikrobielle Proteine als Infektionsschutz der Haut. Fortschritte der praktischen Dermatologie und Venerologie 2010:  531-534.

Gläser R, Köten B, Wittersheim M, Harder J (2011). Psoriasin: key molecule of the cutaneous barrier? Journal of the German Society of Dermatology; 9(11):897-902.

Gläser R, Meyer-Hoffert U, Harder J (2011) Staphylokokken. In Fortschritte der praktischen Dermatologie und Venerologie 2010, 242-246. Hrsg.Ruzicka, Th.; Wolff, H.; Thomas, P.; Prinz, J.

Harder J, Gläser R (2011): Abwehr und Entzündung – Antimikrobielle Proteine als Infektionsschutz. In Fortschritte der praktischen Dermatologie und Venerologie 2010, 531-542. Hrsg.Ruzicka, Th.; Wolff, H.; Thomas, P.; Prinz, J.

Simanski M, Köten B, Schröder JM, Gläser R, Harder J (2012) Antimicrobial RNases in cutaneous defense. Journal of Innate Immunity; 4(3):241-7

Harder J, Schröder JM, Gläser R (2013) The skin surface as antimicrobial barrier: present concepts and future outlooks. Experimental Dermatology.;22:1-5

Harder J, Tsuruta D, Murakami M, Kurokawa I. What is the role of antimicrobial peptides (AMP) in acne vulgaris? (2013) Experimental Dermatology 22(6):386-391

Kopfnagel V, Harder J, Werfel T. Expression of antimicrobial peptides in atopic dermatitis and possible immunoregulatory functions (2013). Curr Opin Allergy Clin Immunol. 13(5):531-536

Cordes J, Wittersheim M, Harder J, Gläser R. (2014) The skin's own antibiotics : Important features of antimicrobial peptides for clinical practice. Hautarzt 65(1):50-55

Simanski M, Gläser R, Harder J. (2014) Human skin engages different epidermal layers to provide distinct innate defense mechanisms. Experimental Dermatology, 23(4):230-231

Harder J. (2016) Tick saliva: paving the way for the stowaway Borrelia. Experimental Dermatology, 25(1): 20-21

Harder J. (2016) Antimikrobielle Peptid (AMP)-Forschung an der Kieler Universitäts-Hautklinik. Aktuelle Dermatologie, 42: 20-22

Biro T, Harder J. (2016) AMP-lification of wound healing. Experimental Dermatology, 25(8):592-593.

Rademacher F, Simanski M, Harder J. (2016) RNase 7 in cutaneous defense. International Journal of Molceular Sciences, 17(4):560.

Gläser R, Harder J. (2017) Research on the skin microbiome : Fascinating and challenging. Hautarzt, 68(9):762-765.

Rademacher F, Simanski M, Gläser R, Harder J. (2018) Skin microbiota and human 3D skin models, Experimental Dermatology, 27(5):489-494.

Rademacher F, Dreyer S, Kopfnagel V, Gläser R, Werfel T, Harder J. (2019) The Antimicrobial and Immunomodulatory Function of RNase 7 in Skin. Front Immunol.5;10:2553.

Emmert H, Rademacher F, Gläser R, Harder J. (2020), Skin microbiota analysis in human 3D skin models - "Free your mice", Experimental Dermatology,  Online ahead of print.

 

 

Book Editor

 Antimicrobial Peptides - Role in Human Health and Disease (2016), published by Springer

 

 

 


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